Effects of Platelet Rich Plasma Injections on Biomarkers After Anterior Cruciate Ligament Tears

Completed · Phase 2

Conditions studied: Anterior Cruciate Ligament Tear, Anterior Cruciate Ligament Rupture

In brief

A potential long-term consequence of anterior cruciate ligament injuries is the development of post-traumatic osteoarthritis in the years following injury. There are no curative treatments for osteoarthritis, increasing the importance of minimizing the occurrence of post-traumatic osteoarthritis following anterior cruciate ligament injuries. Current literature has begun to indicate that biochemical changes in the knee joint cartilage, such as chondrocyte death, following injury can contribute to the development of post-traumatic osteoarthritis. The main objective of this study is to determine if an early intervention of joint aspiration and platelet rich plasma injection will positively affect the biomarkers representative of chondral degeneration in patients with anterior cruciate ligament injuries. We hypothesize that the intervention will reduce the volume of inflammatory and chondrodegenerative biomarkers following anterior cruciate ligament injury.

Key facts

Study ID

NCT04088227

Run by

Andrews Research & Education Foundation

People needed

24

Starts

2019-09-12

Expected to finish

2023-04-21

Last updated by the study team

2025-02-17

Who can join

Age: 14 and older, up to 40. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• No history of previous traumatic ipsilateral knee injury
• Bone bruise visualized on MRI
• No clinical evidence of posterior cruciate ligament injury with no more than grade 1 medial or lateral collateral ligament injury

You may not qualify if…

• Patients without a palpable knee effusion
• An injury occurring more than 10 days before enrollment
• Previous ipsilateral knee surgery
• Intra-articular cortisone or platelet rich plasma injection into either knee within 3 months of injury
• Participation in another clinical drug trial within the 4 weeks before injury
• A history of any inflammatory disease or immune-comprised

Where it is running

• Andrews Institute for Orthopaedics & Sports Medicine — Gulf Breeze, Florida, United States

Full record on ClinicalTrials.gov

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