Restoring Molecular Circadian Rhythm

Paused

Conditions studied: Healthy Young, Healthy Elderly

In brief

The goal is to address the mechanisms that account for alteration of circadian rhythms with age. As the blood of aged individuals can produce this alteration, the investigators propose to use such blood samples to "age" circadian rhythms in cultured cells. The investigators will verify aged blood-dependent alteration of rhythms and then conduct molecular screens to reverse this decline. If the investigators identify specific genes that can restore molecular circadian rhythm in vitro, the investigators will explore these in animal models (Drosophila, mouse).

Key facts

Study ID

NCT04086589

Run by

University of Pennsylvania

People needed

40

Starts

2019-08-19

Expected to finish

2028-11-01

Last updated by the study team

2026-01-23

Who can join

Age: 20 and older, up to 85. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• General good health with the following conditions permissible
• cardiovascular risk prevention, intake of low dose aspirin,
• hypertension, intake of beta-blockers, ACE inhibitors, diuretics, calcium channel blockers
• hypercholesterinemia, intake of statins
• Cases: 70-85 years of age
• Controls: 20-35 years of age
• Patients must be able to read and understand English
• Participants must sign the informed consent form
• Participants must have a wrist-actigraphy-based average TST (total sleep time) ≥ 6 hours per night (measured over 7 consecutive days) occurring between 22:00 - 08:00

You may not qualify if…

• Known history of severe psychiatric or cognitive conditions, for example mania, schizophrenia, or mental retardation
• Shift work, defined as recurring work between 22:00-05:00
• History of clinically significant obstructive sleep apnea
• Transmeridian travel across ≥2 time zones in the two weeks prior to the blood draws and one week after,
• > 2 drinks of alcohol per day
• Use of illicit drugs

Where it is running

• University of Pennsylvania School of Medicine — Philadelphia, Pennsylvania, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.