Tomosynthesis vs. Contrast-Enhanced Mammography in Women With Personal History of Breast Cancer in Western Pennsylvania

Running, not enrolling · Not applicable

Conditions studied: Breast Cancer Female, Breast Cancer, Breast Neoplasms, Neoplasms

In brief

This is a prospective clinical trial that will examine if contrast-enhanced mammography substantially improves breast cancer detection compared to mammography with tomosynthesis, with minimal increase in false-positives, in women with a personal history of breast cancer.

Key facts

Study ID: NCT04085510
Run by: Wendie Berg
People needed: 1647
Starts: 2019-10-23
Expected to finish: 2028-12-30
Last updated by the study team: 2026-03-09

Who can join

Age: 30 and older, up to 85. Sex: female. Healthy volunteers: accepted.

You may qualify if…

Asymptomatic women, ages 30-85, with a personal history of breast cancer who have had at least one routine mammogram since treatment.

You may not qualify if…

Women with a history of prior iodinated contrast reaction
Women with implant(s) in the breasts to be screened (as this creates artifacts and diagnostic performance of imaging in women with implants likely does not generalize to those without implants, and the sample size with implants would be too small to infer conclusions)
Women who have had bilateral mastectomy
Women with a history of kidney failure or estimated glomerular filtration rate (eGFR) < 30 mL/min
Pregnancy or lactation
Women actively being treated for cancer of any type with chemotherapy
Lump or other breast symptoms
Abnormality on prior breast imaging that is being followed.

Where it is running

Magee Womancare Passavant Cranberry — Cranberry Township, Pennsylvania, United States
Magee Womancare Monroeville — Monroeville, Pennsylvania, United States
Magee Womens Hospital — Pittsburgh, Pennsylvania, United States

Full record on ClinicalTrials.gov

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