GEN1042 Safety Trial and Anti-tumor Activity in Participants With Malignant Solid Tumors
Running, not enrolling · Phase 1/Phase 2
Conditions studied: Malignant Solid Tumor, Non-Small Cell Lung Cancer (NSCLC), Colorectal Cancer (CRC), Melanoma, Head and Neck Squamous Cell Carcinoma (HNSCC), Pancreatic Ductal Adenocarcinoma (PDAC)
In brief
The goal of this trial is to learn about the antibody GEN1042 when it is used alone and when it is used together with another antibody cancer drug, pembrolizumab (with or without chemotherapy), for treatment of participants with certain types of cancer.
Key facts
- Study ID
- NCT04083599
- Run by
- Genmab
- People needed
- 350
- Starts
- 2019-09-17
- Expected to finish
- 2027-01-01
- Last updated by the study team
- 2026-08-04
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Cancer & Blood Specialty Clinic — Los Alamitos, California, United States
- Moores Cancer Center at the UC San Diego Health — San Diego, California, United States
- Yale University Cancer Center — New Haven, Connecticut, United States
- ChristianaCare — Newark, Delaware, United States
- Mount Sinai Comprehensive Cancer Center — Miami Beach, Florida, United States
- Florida Cancer Affiliates — Ocala, Florida, United States
- Hope and Healing Cancer Services — Hinsdale, Illinois, United States
- University of Kentucky — Lexington, Kentucky, United States
- Norton Cancer Institute — Louisville, Kentucky, United States
- Maryland Oncology Hematology PA — Columbia, Maryland, United States
- Washington University School of Medicine — St Louis, Missouri, United States
- Levine Cancer Center — Charlotte, North Carolina, United States
- Novant Health Cancer Institute - Forsyth (Medical Oncology) — Winston-Salem, North Carolina, United States
- Kaiser Permanente (KP) Oncology/Hematology — Portland, Oregon, United States
- University of Pennsylvania — Philadelphia, Pennsylvania, United States
- Fox Chase Cancer Center — Philadelphia, Pennsylvania, United States
- Sarah Cannon Research Institute — Nashville, Tennessee, United States
- Lumi Research — Kingwood, Texas, United States
- Utah Cancer Specialists — Salt Lake City, Utah, United States
- Virgina Cancer Specialists — Fairfax, Virginia, United States
- Adventist Health System/Sunbelt,Inc — Seattle, Washington, United States
- Medical Oncology Associates, PS — Spokane, Washington, United States
- Rigshospitalet (Copenhagen University Hospital) — Copenhagen, Denmark
- Herlev University Hospital — Herlev, Denmark
- Alaska Oncology and Hematology LLC — Anchorage, Alaska, United States
Full record on ClinicalTrials.gov
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