Effect of G6PD Deficiency on Red Blood Cell Storage
Completed
Conditions studied: G6PD Deficiency
In brief
The proposed study will determine whether G6PD-deficient RBCs store differently than normal RBCs under standard blood banking conditions. The investigators plan to screen a large number of healthy male volunteers for G6PD deficiency in order to identify 10 G6PD deficient and 30 matched normal individuals using a blood sample obtained from a finger-stick. The identified individuals will then be asked to donate a unit of blood that will be stored for up to 42 days and various tests will be performed on these units during storage. At 6 weeks of storage a portion of the unit will be radioactively labeled and re-infused into the volunteer. Blood samples will be drawn before, during, and after the infusion to measure how well or poorly the red blood cells survive after transfusion.
Key facts
- Study ID
- NCT04081272
- Run by
- Columbia University
- People needed
- 40
- Starts
- 2012-11-01
- Expected to finish
- 2017-10-01
- Last updated by the study team
- 2019-09-17
Who can join
Age: 18 and older, up to 70. Sex: male. Healthy volunteers: accepted.
You may qualify if…
- Male
- Weight greater than 110 pounds
- Hemoglobin greater than 11.5 g/dL
- African (e.g., Afro-American, Afro-Caribbean, Sub-Saharan), Asian, Hispanic, Middle Eastern, or Mediterranean (e.g., Italian, Greek) based on mother's ancestry
- English speaking
You may not qualify if…
- Presence of hemoglobin variant
- Ineligible for donation based on the New York Blood Center donor autologous questionnaire
- Systolic blood pressure >180 or <90 mm Hg, diastolic blood pressure >100 or <50 mm Hg
- Heart rate <50 or >100
- Temperature >99.5°F prior to donation
- Temperature >100.4°F or subjective feeling of illness prior to transfusion (this criterion is to avoid concurrent illness affecting post-transfusion measurements)
- Positive results on standard blood donor infectious disease testing
Where it is running
- Columbia University Irving Medical Center — New York, New York, United States
- New York Blood Center — New York, New York, United States
Full record on ClinicalTrials.gov
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