Volume vs Concentration: Quadratus Lumborum Blocks With High Volume/Low Concentration or Low Volume/ High Concentration in Nephrectomies

Withdrawn before enrolling · Phase 4

Conditions studied: Analgesia, Postoperative Pain, Block

In brief

The quadratus lumborum has since 2016 become standard of care for abdominal and retroperitoneal surgeries at UPMC-Shadyside Hospital, replacing paravertebral blocks, and as part of a broader multimodal analgesia institutional Enhanced Recovery After surgery protocol. Since the first description of this technique, several approaches to and anatomic targets within the quadratus lumborum plane have been described although their mechanism of action, spread, and relative clinical effectiveness remain areas of some debate. What is proposed here is to investigate the relative clinical effectiveness of the relationship high volume/low concentration of local anesthetic or low volume/ high concentration of local anesthetic.

Key facts

Study ID

NCT04077398

Run by

Bruce Ben-David

People needed

0

Starts

2020-01-22

Expected to finish

2021-08-01

Last updated by the study team

2021-02-16

Who can join

Age: 18 and older, up to 90. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients 18-90 years old
• Patients undergoing nephrectomy
• Body Mass Index 19-36
• Male and Female
• All races
• American Society of Anesthesiologist scale I, II, III

You may not qualify if…

• Patient refusal
• Pregnancy
• Non-English speaking or inability to participate in the study
• Patients with coagulopathy or With International Normalized Ratio >1,5 the day of the surgery.
• Chronic steroid use
• Chronic pain
• Chronic opiate use

Where it is running

• UPMC shadyside hospital — Pittsburgh, Pennsylvania, United States

Full record on ClinicalTrials.gov

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