High-intensity Interval Training for Obese Individuals
Stopped early · Not applicable
Conditions studied: Obesity, Insulin Resistance
In brief
This proposal's objective is to investigate the effects of a high-intensity intermittent stair climbing program on insulin resistance in individuals with obesity and at risk of type 2 diabetes (T2D). Obesity (defined as body mass index ≥ 30kg/m2) is a major risk factor for T2D. The connection between obesity and T2D involves the development of insulin resistance (IR). Exercise training is an effective non-pharmacological approach to prevent and treat IR. Despite the efficacy of exercise training on ameliorating IR, most individuals do not achieve the minimum recommended levels of physical activity and cite "lack of time" and difficulty in accessing exercise facilities as barriers to exercise. Proposed as a time-efficient alternative, high-intensity interval training (HIIT), which consists of short periods of high-intensity efforts alternated with brief periods of recovery, is an efficient strategy to improve IR. However, most HIIT protocols have been studied in laboratory-based settings requiring access to specialized equipment (i.e. treadmills, cycle ergometers) and are not practical for the general population. The use of high-intensity intermittent stair climbing may be a suitable exercise strategy from an accessibility perspective. With evidence to suggest improvements in IR following HIIT in individuals with obesity or T2D, the application of a similar approach using high-intensity intermittent stair climbing to directly assess changes in IR in a population at risk of T2D populations is warranted. Completion of this study will help elucidate if an easy to implement, time-efficient and low-cost exercise training program improves insulin resistance in individuals at risk of T2D.
Key facts
- Study ID
- NCT04075799
- Run by
- University of New Mexico
- People needed
- 18
- Starts
- 2022-01-01
- Expected to finish
- 2023-05-12
- Last updated by the study team
- 2024-01-25
Who can join
Age: 18 and older, up to 45. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- 18-45 years,
- body mass index (BMI) equal or superior than 30 kg/m²;
- homeostasis model assessment for insulin resistance (HOMA-IR) ≥ 2.71,
- no fear of being totally submerged underwater for 2 to 10 seconds
- comfortable having blood taken from a forearm vein.
You may not qualify if…
- smokers,
- currently taking any medications known to impact their metabolism or immune system,
- bleeding or blood clotting disorder,
- physical injury,
- physical limitations,
- diagnostic of T2D,
- currently under the active care of a physician for any condition that may interfere with their safety.
- cardiovascular conditions (cardiac, peripheral vascular, or cerebrovascular disease),
- diseases that prevent participation in a maximal effort test without physician clearance per the American College of Sports Medicine (ACSM) guidelines (2017).
- signs and symptoms of cardiovascular disease, at rest or during physical activity, which includes pain, discomfort in the chest, neck, jaw, arms, or other areas that may result from ischemia; shortness of breath at rest or with mild exertion; dizziness or syncope; orthopnea or paroxysmal nocturnal dyspnea; ankle edema; palpitations or tachycardia; intermittent claudication; known heart murmur; or unusual fatigue or shortness of breath with usual activities.
Where it is running
- Fabiano Trigueiro Amorim — Albuquerque, New Mexico, United States
Full record on ClinicalTrials.gov
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