The MOMENTUM Study: The Multiple Outcome Evaluation of Radiation Therapy Using the MR-Linac Study

Recruiting now

Conditions studied: Oncology, Breast Cancer, Prostate Cancer, Gynecologic Cancer, Brain Tumor, Brain Cancer, Gynecologic Tumor, Prostate Tumor, Prostate Neoplasm, Breast Tumor, Radiation Toxicity, Quality of Life, Rectal Cancer, Rectal Tumor, Rectal Neoplasms, Lung Cancer, Lung Tumor, Lung Neoplasm, Esophageal Cancer, Esophagus Cancer, Esophageal Tumor, Esophageal Neoplasm, Esophagus Tumor, Esophagus Neoplasm, Pancreatic Cancer, Pancreatic Tumor, Pancreatic Neoplasms, Head and Neck Cancer, Head and Neck Neoplasms, Head and Neck Tumor, Tumor, Neoplasms, Bladder Cancer, Bladder Neoplasm, Liver Cancer, Liver Neoplasms, Liver Metastases, Oligometastases

In brief

The Multi-OutcoMe EvaluatioN of radiation Therapy Using the Unity MR-Linac Study (MOMENTUM) is a multi-institutional, international registry facilitating evidenced based implementation of the Unity MR-Linac technology and further technical development of the MR-Linac system with the ultimate purpose to improve patients' survival, local, and regional tumor control and quality of life.

Key facts

Study ID

NCT04075305

Run by

UMC Utrecht

People needed

8000

Starts

2019-02-01

Expected to finish

2030-08-01

Last updated by the study team

2026-03-05

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patient is to undergo or has completed imaging or treatment procedures on an MR-Linac;
• Patient provides written, informed consent;
• Patient is 18 years old or older.

You may not qualify if…

• MRI exclusion criteria, including
• MRI contraindications as per usual clinical care, such as (possible) pregnancy; claustrophobia and metal or electronic implants not compatible with MRI.

Where it is running

• Allegheny Health Network — Pittsburgh, Pennsylvania, United States (enrolling)
• Md Anderson Cancer Center — Houston, Texas, United States (enrolling)
• Medical College of Wisconsin — Milwaukee, Wisconsin, United States (enrolling)
• Radboud UMC — Nijmegen, Netherlands (enrolling)
• University Medical Center Utrecht — Utrecht, Netherlands (enrolling)
• The Royal Marsden and The Institute of Cancer Research National Institute for Health Research Biomedical Research Centre — London, United Kingdom (enrolling)
• The Christie National Health Service Foundation Trust — Manchester, United Kingdom (enrolling)
• Sunnybrook Health Sciences Centre/Odette Cancer Centre — Toronto, Ontario, Canada (enrolling)
• University Health Network - Princess Margaret Cancer Center — Toronto, Canada (enrolling)
• Odense Universitetshospital — Odense, Funen, Denmark (enrolling)
• Universitätsklinikum Tübingen — Tübingen, Germany (enrolling)
• IRCCS Ospedale Sacro Cuore Don Calabria — Negrar, Italy (enrolling)
• Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital — Amsterdam, Netherlands (enrolling)
• Radiotherapiegroep — Deventer, Netherlands (enrolling)
• Austin Health - Olivia Newton-John Cancer Wellness and Research Centre — Melbourne, Australia
• Insitut Jules Bordet — Brussels, Belgium
• Università degli Studi di Brescia — Brescia, Italy
• Radiotherapeutisch Instituut Friesland (RIF) — Leeuwarden, Netherlands

Full record on ClinicalTrials.gov

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