Pharmacist Intervention to Reduce Post-Hospitalization Utilization

Running, not enrolling · Not applicable

Conditions studied: Nonadherence, Patient, Polypharmacy, Readmission

In brief

This is a randomized trial testing a peri- and post-discharge pharmacist-led medication management intervention on post-discharge utilization, including both readmissions and emergency department visits within 30 days of discharge. The intervention incorporates evidence addressing three main areas: medication reconciliation, medication adherence, and polypharmacy. This study uses a pragmatic trial randomized at the patient level and conducted in two large hospitals to achieve the following aims, each of which has been designed using the RE-AIM framework: Aim 1: To test the effect of PHARM-DC on post-discharge utilization among patients most at risk for post-discharge ADEs: recently discharged older adults taking \>10 medications or \>3 high-risk medications using a prospective, randomized, pragmatic multi-site study. Aim 2: To study barriers and facilitators of implementing PHARM-DC using a qualitative study. Aim 3: To analyze the costs of PHARM-DC, including the incremental cost per readmission averted and the net incremental cost from the health system perspective using a time-and-motion study and a cost-effectiveness analysis.

Key facts

Study ID

NCT04071951

Run by

Cedars-Sinai Medical Center

People needed

6478

Starts

2019-12-23

Expected to finish

2027-01-01

Last updated by the study team

2026-04-02

Who can join

Age: 55 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Admitted to a medical ward, AND
• > 55 years AND
• ≥ 10 prescription medications at admission
• OR
• ≥ 3 high-risk medications (anticoagulants, antiplatelets, insulin, oral hypoglycemics) at admission

You may not qualify if…

• Expected discharge to another state, acute care facility, psychiatric facility, or locked facility (including locked skilled nursing facility, jail, or prison) OR
• Expected AMA or left hospital against medical advice (AMA) OR
• Homeless OR
• On hospice OR
• Already enrolled into study within the past year OR
• Patients admitted by admitting or attending Primary Medical Doctors who have a specialty that is not Internal Medicine or Family Medicine OR
• Expected to receive pharmacist-led peri- and post-discharge medication management regardless of the trial OR
• Expected post-discharge setting not conducive to the studied medication management intervention (e.g. SNF, rehabilitation facility) OR
• Patients admitted with a suspected or confirmed diagnosis of COVID-19.

Where it is running

• Cedars-Sinai Medical Center — Los Angeles, California, United States
• Brigham and Women's Hospital — Boston, Massachusetts, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.