Correlation of Radiological Lesions With Vestibular Function in Patients With Bilateral Vestibulopathy
Recruiting now
Conditions studied: Hearing Loss, Sensorineural, Bilateral Vestibular Deficiency, DFNA9, Radiology
In brief
In 2014 radiologic lesions were detected at one or more semicircular canals using CT and MR imaging of temporal bone in subjects carrying the p.P51S mutation in COCH. These lesions are believed to present at more advanced stages of the hearing and vestibular deterioration. Since then, other authors have described similar lesions in advanced non-genetic hearing and vestibular impairment as well. The purpose of this study is therefore to assess the radiologic investigation using CT and MR imaging of temporal bone to all subjects presenting with bilateral vestibulopathy, using the Barany criteria, compared to the p.P51S population.
Key facts
- Study ID
- NCT04070937
- Run by
- Jessa Hospital
- People needed
- 40
- Starts
- 2019-09-01
- Expected to finish
- 2026-10-30
- Last updated by the study team
- 2021-08-25
Who can join
Age: 18 and older, up to 90. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- must meet the Barany criteria for bilateral vestibulopathy: bilaterally pathological horizontal angu- lar VOR gain <0.6, measured by the video-HIT5 or scleral-coil technique and/or
- reduced caloric response6 (sum of bither- mal max. peak SPV on each side <6◦/sec7) and/or
- reduced horizontal angular VOR gain <0.1 upon sinusoidal stimulation on a rota- tory chair (0.1 Hz, Vmax = 50◦ /sec) and a phase lead >68 degrees (time constant <5 sec).
- must be 18 or older
You may not qualify if…
- < 18 y
- does not meet Barany criteria for BV
- contraindication for CT and MR imaging
Where it is running
- Jessa Hospital — Hasselt, Limburg, Belgium (enrolling)
Full record on ClinicalTrials.gov
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