Mechanisms of Exercise Intolerance in Heart Failure With Preserved Ejection Fraction

Completed · Not applicable

Conditions studied: Heart Failure, Diastolic

In brief

The global objective of this study is to determine the mechanisms of exercise intolerance and dyspnea on exertion (DOE) in patients with HFpEF and based on this pathophysiology, test whether specific exercise training programs (whole body vs single leg) will result in improved exercise tolerance.

Key facts

Study ID

NCT04068844

Run by

University of Texas Southwestern Medical Center

People needed

93

Starts

2019-08-01

Expected to finish

2026-04-01

Last updated by the study team

2026-06-03

Who can join

Age: 60 and older, up to 90. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• signs and symptoms of heart failure
• an ejection fraction > 0.50
• objective evidence of diastolic dysfunction

You may not qualify if…

• age < 60 years
• BMI > 50 kg/m2
• PDE5 inhibitor use
• Severe valvular disease
• Severe COPD
• CKD 4 or higher
• Contra-indication to MRI.

Where it is running

• The Institute for Exercise and Environmental Medicine — Dallas, Texas, United States

Full record on ClinicalTrials.gov

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