Effects of Age on Amino Acid Delivery to Tendon

Completed · Not applicable

Conditions studied: Aging

In brief

Dietary amino acid supplementation may provide an effective means to promote tendon injury recovery and enhance collagen synthesis. While most published research has been completed in animal models, research with young adults has shown that a leucine-rich whey isolate consumed during a chronic resistance training (RT) intervention resulted in greater gains (\~60%) in tendon CSA when compared to placebo. Leucine-rich diets have also improved tendon collagen content in rodents. Further, in our preliminary work utilizing microdialysis, we demonstrate that oral consumption of a leucine-rich amino acid beverage increased delivery of amino acids to tendons in young adults (21-30 years). However, whether aging alters the delivery of amino acids to tendons after oral consumption has not be investigated. In order to optimize amino acid dosing for chronic interventional studies, we wish to determine if aging influences amino acid concentration in the peritendinous (space around the tendon) space after oral consumption.

Key facts

Study ID

NCT04064528

Run by

Purdue University

People needed

20

Starts

2019-09-06

Expected to finish

2023-08-01

Last updated by the study team

2023-12-14

Who can join

Age: 21 and older, up to 75. Sex: any. Healthy volunteers: accepted.

You may not qualify if…

• body mass index >35 kg•m-2, those on medications known to affect protein or collagen metabolism, e.g. acetaminophen, ibuprofen, or prescription cyclooxygenase inhibitors, previous history of tendinopathy, or diabetes.

Where it is running

• Purdue University — West Lafayette, Indiana, United States

Full record on ClinicalTrials.gov

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