AMI Construction in Lower Extremity Residual Limbs

Recruiting now · Not applicable

Conditions studied: Amputation

In brief

This study will involve the development of a novel approach to lower extremity residual limb surgical revision that offers the promise of augmenting volitional motor control, restore proprioception and reverse atrophy

Key facts

Study ID

NCT04063592

Run by

Brigham and Women's Hospital

People needed

26

Starts

2020-02-24

Expected to finish

2026-09-30

Last updated by the study team

2026-07-09

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Between the ages of 18-65
• Has already undergone a standard AKA or BKA procedure
• Suffers from symptoms such as:
• Intractable pain
• Deterioration of skin on or around stump
• Suffering from other sources of discomfort arising from stump
• Intact inherent wound healing
• Adequate communication skills
• High motivation

You may not qualify if…

• Inadequate health to undergo operative procedure using standard anesthesia (i.e. cardiopulmonary)
• Individuals with impaired wound healing
• Individuals suffering from extensive peripheral neuropathies
• Active smokers
• Individuals with a history of poor compliance
• Women who are pregnant or plan to become pregnant before surgical intervention

Where it is running

• Brigham and Women's Hospital — Boston, Massachusetts, United States (enrolling)
• Massachusetts Institute of Technology — Cambridge, Massachusetts, United States (enrolling)
• Walter Reed National Military Medical Center — Bethesda, Maryland, United States

Full record on ClinicalTrials.gov

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