The Use of Focused Ultrasound and DCE K-trans Imaging to Evaluate Permeability of the Blood-Brain Barrier

Enrolling by invitation · Not applicable

Conditions studied: Low Grade Glioma of Brain

In brief

The limitation of treating intrinsic brain pathologies has been circumvented with neurosurgical techniques; however, less invasive approaches may be desirable particularly for widespread or multifocal disease and when long term and repetitive administration is required. This study seeks to investigate the efficacy of focused ultrasound. Patients with either low grade gliomas or neurodegenerative dementias will be evaluated for study candidacy. There are no immediate benefits for patients who choose to participate; however, the information gained from this study will contribute to the research base and help patients in similar situations in the future.

Key facts

Study ID

NCT04063514

Run by

Neurological Associates of West Los Angeles

People needed

15

Starts

2021-06-11

Expected to finish

2027-01-20

Last updated by the study team

2023-03-24

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Subjects undergoing routine, repetitive MRI scanning for monitoring low grade gliomas
• 18 or older

You may not qualify if…

• Cognitive decline with mild cognitive impairment (Clinical Dementia Rating stage 0.5) through moderate dementia CDR stages 1 and 2

Where it is running

• Neurological Associates of West LA — Santa Monica, California, United States

Full record on ClinicalTrials.gov

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