Impact of Increased Immunoglobulin E to Anti-herpes Simplex Virus -1 Innate Immune Responses in Atopic Dermatitis Patients With Eczema Herpeticum
Status unconfirmed
Conditions studied: Atopic Dermatitis With a History of Eczema Herpeticum, Atopic Dermatitis Without a History of Eczema Herpeticum, Health Controls Without Atopy
In brief
This study investigates whether blood monocytes' surface bound- immunoglobulin E affects the innate immune responses against herpes simplex viruses in atopic dermatitis patients with eczema herpeticum.
Key facts
- Study ID
- NCT04060550
- Run by
- National Jewish Health
- People needed
- 36
- Starts
- 2020-01-09
- Expected to finish
- 2021-07-31
- Last updated by the study team
- 2021-03-05
Who can join
Age: 16 and older, up to 65. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Age 16-65 years old, age, sex and race match among non-atopic, ADEH- and ADEH+.
- Participant and/or parent guardian must be able to understand and provide informed consent, and fits in one of the following conditions:
- A history of AD with a history of eczema herpeticum, ADEH+, as diagnosed using the Atopic Dermatitis Research Network Standard Diagnostic Criteria.
- A history of AD without a history of eczema herpeticum, ADEH-, as diagnosed using Atopic Dermatitis Research Network Standard Diagnostic Criteria, and no first degree relatives with a history of EH.
- Non-atopic as diagnosed using Atopic Dermatitis Research Network Standard Diagnostic Criteria.
You may not qualify if…
- Inability or unwillingness of a participant to give written informed consent or comply with study protocol
- Known or suspected immunosuppression
- Severe concomitant illness(es)
- Women of childbearing potential not using the contraception method(s) specified in this study (specify), as well as women who are breastfeeding
- Known sensitivity to study drug(s) or class of study drug(s)
- Patients with severe medical condition(s) that in the view of the investigator prohibits participation in the study (specify as required)
- Use of any other investigational agent in the last 30 days
Where it is running
- National Jewish Health — Denver, Colorado, United States (enrolling)
Full record on ClinicalTrials.gov
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