DBS and Respiration
Recruiting now
Conditions studied: Parkinson Disease
In brief
Patients referred to neurosurgery routinely and safely undergo deep brain stimulation (DBS) for treatment of neurological conditions, most commonly Parkinson's disease. The investigators have observed that respiratory problems (breathlessness) sometimes occur subsequent to DBS of the subthalamic nucleus (STN). This study aims to determine whether this is indeed a consequence of STN stimulation. Secondary objectives include identification of the respiratory physiological mediators of any interoceptive neuromodulation observed, changes in daily physical activity and MRI structural connectivity analysis.
Key facts
- Study ID
- NCT04058457
- Run by
- University of Oxford
- People needed
- 60
- Starts
- 2021-04-01
- Expected to finish
- 2026-09-21
- Last updated by the study team
- 2025-03-27
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Participant is willing and able to give informed consent for participation in the study.
- Male or female, aged 18 years or above.
- Planned for required DBS surgery
- Fluent in the English language
- For experimental group: diagnosed with Parkinson's disease
You may not qualify if…
- Female who is pregnant
- Subject is currently participating in a clinical investigation that includes an active treatment arm which may affect the respiratory system.
- Acute respiratory problem at time of experimental session: e.g. rhinosinusitis, pharyngitis, asthma exacerbation
Where it is running
- John Radcliffe Hospital — Oxford, Oxfordshire, United Kingdom (enrolling)
Full record on ClinicalTrials.gov
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