Osteopathic Manipulation Makes a Neuropsychological Difference
Running, not enrolling · Not applicable
Conditions studied: Cognitive Change, Musculoskeletal Pain
In brief
Patients with pain commonly experience cognitive impairment. While symptoms of pain are effectively treated with osteopathic manipulative treatment (OMT), the cognitive piece is vastly ignored. Pain-induced cognitive dysfunction can be severe and is particularly apparent in working memory and attention. There is good reason to also expect cognitive responsiveness to OMT. Previous research has already reported related psychiatric outcomes, including relief from stress, self-perception and anxiety, suggesting that OMT may produce more global effects on cortical processing than currently thought.
Key facts
- Study ID
- NCT04058431
- Run by
- Midwestern University
- People needed
- 100
- Starts
- 2017-01-01
- Expected to finish
- 2026-09-01
- Last updated by the study team
- 2025-09-30
Who can join
Age: 40 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- 40 years of age or older;
- seeking treatment for acute or chronic pain (neck, thoracic, shoulder, back)
- gives a positive response to the item, "Have you had thinking problems because of your pain?";
- agree to forego extra-trial manipulation (e.g., massage, chiropractic, physical therapy);
- Score > 23 on the Telephone Interview for Cognitive Status;
- written informed consent.
You may not qualify if…
- recent (< 2 month) or planned surgery within the duration of the study;
- use of medication that could interfere with cytokine measurements;
- recent (< 2 month) changes to psychotropic medication within the duration of the study;
- history of manipulation within the past six months.
- diagnosed neurocognitive disorders;
- contraindication to receiving OMT.
Where it is running
- Midwestern Multispecialty Clinic — Downers Grove, Illinois, United States
Full record on ClinicalTrials.gov
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