tSCI Contrast Enhanced Ultrasound Study
Completed · Phase 4
Conditions studied: Acute Spinal Cord Injury
In brief
Patients with traumatic spinal cord injury (tSCI) often suffer from spinal cord swelling inside the thecal sac, which contains the spinal cord and surrounding fluid, leading to increased pressure on the spinal cord tissue and decreased spinal cord blood flow at the site of injury. The combination of increased pressure and decreased blood flow causes vascular hypo-perfusion of the spinal cord and exacerbates the severity of the injury. This is also referred to as secondary injury. Thus, knowledge of spinal cord hypo-perfusion would allow the treating physician to optimize the hemodynamic condition of patients with acute spinal cord injury and potentially improve functional outcomes. The investigators plan to use contrast-enhanced ultrasound (CEUS) to determine the decrease of blood flow in the spinal cord at the site of injury, during the routine surgery that these patients require to decompress and stabilize their injured spine. This may help the investigators to determine the efficacy of certain treatments in improving blood flow and patients suffering from tSCI.
Key facts
- Study ID
- NCT04056988
- Run by
- University of Washington
- People needed
- 27
- Starts
- 2018-07-31
- Expected to finish
- 2023-11-20
- Last updated by the study team
- 2026-07-13
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- >18
- Male or Female
- Acute <72 hours spinal cord injury (ASIA) grade A to D
- Medically stable to undergo routine decompression and spinal realignment
You may not qualify if…
- <18 years of age
- Not clinically stable for spinal surgery
- Traumatic Brain Injury
- Known sensitivity to lipid microsphere or its components i.e., (PEG).
- A history of anaphylactoid reactions from ultrasound-enhancing agents
Where it is running
- Harborview Medical Center — Seattle, Washington, United States
Full record on ClinicalTrials.gov
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