Biomarkers in Neurodegenerative Diseases
Withdrawn before enrolling
Conditions studied: Mild Cognitive Impairment (MCI), Alzheimer Disease (AD), Dementia With Lewy Bodies (DLB), Frontotemporal Lobar Degeneration (FTLD), Parkinsons Disease With Dementia (PDD), Transient Epileptic Amnesia (TEA), Temporal Lobe Epilepsy (TLE), Spinocerebellar Ataxias (SCA), HIV Associated Neurocognitive Disorder (HAND), Amyotrophic Lateral Sclerosis (ALS), Primary Lateral Sclerosis (PLS)
In brief
The general purpose of this observational study is to examine biomarkers associated with the pathology of neurodegenerative diseases to potentially develop novel therapeutic approaches.
Key facts
- Study ID
- NCT04055532
- Run by
- University of Minnesota
- People needed
- 0
- Starts
- 2019-10-01
- Expected to finish
- 2025-10-01
- Last updated by the study team
- 2019-11-12
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Diagnosis of MCI, AD, DLB, FTLD, PDD, TEA, TLE, SCA, HAND, ALS, PLS, or normal control.
- Age 18 or older
- Reliable informant with frequent contact with participant
- Mini Mental State Exam (MMSE) ≥15 AND/OR Clinical Dementia Rating (CDR) less than 2
- Able to undergo extensive psychometric testing
You may not qualify if…
- Any conditions that could account for cognitive deficits in addition to a neurodegenerative disease, including but not limited to:
- Past or present diagnosis of Korsakoff's syndrome
- Alcohol or substance abuse preceding dementia \& still present within 5 years of onset
- Present untreated vitamin B12 or folate deficiency
- Present untreated hypothyroidism
- Past or present head trauma with persistent deficits
- Present untreated syphilis
- Past or present multiple sclerosis or another neuro-inflammatory disorder
- Past or present vascular or multi-infarct dementia
- Past or present diagnosis of huntington's disease
- Past or present normal pressure hydrocephalus
- Past or present central nervous system (CNS) lesions deemed to be clinically significant
- Unresolved or present subdural hematoma
- Past or present Ischemic Vascular Dementia
- Past or present intracerebral hemorrhage
- Present systematic liver disease
- Present renal insufficiency requiring dialysis
- Present encephalitis or meningitis
- Present anxiety disorder (not due to dementia and requiring medication more than 3x per week)
- Present severe periventricular white matter disease or greater than grade 4 white matter lesions
- Present lacunar infarcts deemed to clinically significant
- Present cortical stroke
- Present respiratory condition requiring oxygen
- Present significant systemic medical illness, such as cancer requiring chemotherapy or end stage cardiac insufficiency
- Present inability to safely scan in an MRI
Where it is running
- University of Minnesota — Minneapolis, Minnesota, United States
Full record on ClinicalTrials.gov
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