Evaluation of Urinary Exosomes Presence From Clear Cell Renal Cell Carcinoma

Recruiting now

Conditions studied: Clear Cell Renal Cell Carcinoma

In brief

Clear cell renal cell carcinoma is diagnosed by imaging, sometimes associated with biopsy. This diagnosis is expensive, invasive and sometimes late. The development of a simple biological test for diagnosis is essential. Exosomes are 30 to 150 nm membrane vesicles secreted into the extracellular space by various living cells. These exosomes can be isolated from biological fluids, including urine. The recent study of urinary exosomes is a promising topic for analyzing tumor markers in urine. The investigator's goal is to develop a reliable technique for detecting tumor exosomes in urine in patients with clear cell renal cell carcinoma. The analysis of urinary exosomes could provide a new liquid biopsy tool for the early diagnosis of clear cell renal cell carcinoma.

Key facts

Study ID

NCT04053855

Run by

Centre Hospitalier Universitaire de Saint Etienne

People needed

100

Starts

2020-01-29

Expected to finish

2026-08-01

Last updated by the study team

2026-05-06

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients:
• All patients with renal mass requiring surgery (partial or total nephrectomy)
• Social security affiliation
• Signed informed consent
• Control :
• Unscheduled nephrectomy
• Social security affiliation
• Signed informed consent

You may not qualify if…

• Insufficient volume of urine sample (< 100 ml)
• Patients with a urinary catheter
• Patients under court-ordered guardianship or curators

Where it is running

• Chu Saint-Etienne — Saint-Etienne, France (enrolling)

Full record on ClinicalTrials.gov

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