An Extension Study of IMR-687 in Adult Patients With Sickle Cell Anemia

Running, not enrolling · Phase 2

Conditions studied: Sickle Cell Disease

In brief

This is an open-label extension study of IMR-687 in adult patients who completed Imara's blinded Phase 2a study (IMR-SCD-102). The open-label extension study will evaluate long-term safety and tolerability.

Key facts

Study ID

NCT04053803

Run by

Imara, Inc.

People needed

30

Starts

2019-05-22

Expected to finish

2025-03-01

Last updated by the study team

2022-03-04

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Completed Study IMR-SCD-102.
• Female subjects must not be pregnant, not be breast feeding, and be highly unlikely to become pregnant. Male subjects must be unlikely to impregnate a partner.
• Subjects must be capable of giving informed consent and reading and signing the informed consent form after the nature of the study has been fully explained to them
• Subjects must be willing and able to complete all study assessments and procedures and to communicate effectively with the investigator and site staff.

You may not qualify if…

• Subjects with Hb >12.5 g/dL or <6 g/dL
• Subjects with known active hepatitis B or hepatitis C, with active or acute event of malaria or who are known to be positive for human immunodeficiency virus (HIV)
• eGFR <50 mL/min
• AST/ALT > 3x the upper limit of normal

Where it is running

• University of Connecticut Health Center — Farmington, Connecticut, United States
• Foundation for Sickle Cell Disease Research — Hollywood, Florida, United States
• Baylor Scott & White Medical Center - Temple — Temple, Texas, United States
• Bristol Haematology and Oncology Centre — Bristol, United Kingdom
• University College London Hospital NHS Foundation Trust — London, United Kingdom
• Guy's and St Thomas Hospital CRF — London, United Kingdom
• Royal London Hospital — London, United Kingdom

Full record on ClinicalTrials.gov

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