Evaluating Ketamine and Psychological Sequelae

Completed

Conditions studied: Pain, Ketamine Infusion, Psychologic Sequelae

In brief

The purpose of this study is to examine the relationship between the use of intravenous infusion of sub-anesthetic dosages of ketamine given for pain to combat casualties and emerging symptoms of Post-Traumatic Stress Disorder (PTSD), depression, anxiety, sleep disruption, and risk of alcohol abuse as identified with behavioral health screening tools. Although ketamine has gained popularity as an analgesic agent, literature related to its psychological impact is sparse.

Key facts

Study ID

NCT04053400

Run by

Defense and Veterans Center for Integrative Pain Management

People needed

159

Starts

2014-12-01

Expected to finish

2017-09-13

Last updated by the study team

2019-08-12

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Group I. Ketamine Group
• Active duty military service member injured in theater and treated at WRAMC or at WRNMMC
• 18 years of age or older
• Completed the PBBHA or PDHAT initial and follow up assessment post aerovac from theater
• Received ketamine infusion to treat pain after aero-evacuation for inpatient medical care between Sep 2005 and June 2014
• Received ketamine before completion of the PDHAT or PDBHA follow-up assessment
• ISS scores are available for each individual
• Group II. Non-Ketamine Comparison Group
• Active duty military service member injured in theater and treated at WRAMC or at WRNMMC
• 18 years of age or older
• Completed the PBBHA or PDHAT initial and follow up assessment post aerovac from theater
• Did not receive ketamine treatment for pain after aero-evacuation for inpatient medical care before follow-up
• ISS are available for each individual
• Patient will have ISS scores similar to a Ketamine Group patient and a similar timing of injury to the same Ketamine Group patient.

You may not qualify if…

• Not treated by WRNMMC/WRAMC hospital staff between Sep 2005 and June 2014
• Not active duty, activated National Guard, or activated Reserve service members
• Younger than 18 years of age
• Did not complete the PDBHA or PDHAT initial and follow-up assessments
• ISS scores are not available

Where it is running

• Walter Reed National Military Medical Center — Bethesda, Maryland, United States

Full record on ClinicalTrials.gov

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