Avelumab With Bempegaldesleukin With or Without Talazoparib or Enzalutamide in Advanced or Metastatic Solid Tumors

Stopped early · Phase 1/Phase 2

Conditions studied: Squamous Cell Carcinoma of the Head and Neck (SCCHN), Metastatic Castration Resistant Prostate Cancer (mCRPC)

In brief

Evaluation of the combination of avelumab + bempegaldesleukin (NKTR-214 ) in locally advanced squamous cell carcinoma of the head and neck ( metastatic SCCHN) and avelumab + bempegaldesleukin (NKTR-214) + talazoparib or enzalutamide in metastatic castration resistant prostate cancer (mCRPC).

Key facts

Study ID

NCT04052204

Run by

Pfizer

People needed

3

Starts

2019-12-30

Expected to finish

2020-09-29

Last updated by the study team

2021-10-14

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Participants must be ≥ 18 years old.
• Participants with SCCHN or mCRCP.
• Participants must have histological diagnosis of solid tumors and provide tumor tissue.
• Measurable disease by RECIST v1.1 with at least 1 measurable lesion.
• Eastern Cooperative Oncology Group (ECOG) Performance Status (PS) 0 or 1.
• Adequate bone marrow, renal and liver function
• Highly effective contraceptive use by men with the ability to father a child or women of childbearing potential.
• A WOCBP must have a negative highly sensitive pregnancy test ([urine or serum] as required by local regulations) at C1D1.
• Signed and dated informed consent.

You may not qualify if…

• Known prior severe hypersensitivity to investigational products or any component in their formulations, including known severe hypersensitivity reactions to monocolonal antibodies.
• Known history of: immune-mediated colitis, inflammatory bowel disease, pneumonitis, or pulmonary fibrosis.
• Active or prior autoimmune disease that might deteriorate when receiving an immunostimulatory agent.
• Prior organ transplantation including allogenic stem cell transplantation.
• Vaccination within 4 weeks prior to C1D1 and while on trial is prohibited except for administration of inactivated vaccines.
• Known symptomatic brain lesions requiring steroids.
• Known history of testing positive for human immunodeficiency virus (HIV or known acquired immunodeficiency syndrome (AIDS).
• Positive HBV surface antigen or HCV test indicating acute or chronic infection..
• Active infection requiring systemic therapy
• Clinically significant (i.e., active) cardiovascular disease including the following: documented left ventricular ejection fraction (LVEF) <50% by ECHO/MUGA; cerebral vascular accident/stroke or transient ischemic attack; myocardial infarction; unstable angina; congestive heart failure or serious cardiac arrhythmia (uncontrolled, clinically significant) requiring medication.
• Diagnosis of any other malignancy within 2 years prior to C1D1, except for adequately treated basal cell or squamous cell skin cancer, carcinoma in situ of the breast, bladder or of the cervix and for Combination A only, low-grade (Gleason 6 or below) prostate cancer on surveillance with no plans for treatment intervention (e.g., surgery, radiation, or castration) or adequately treated prostate cancer.
• Current use of immunosuppressive medication at the time of study enrollment.
• Major surgery within 4 weeks prior to study enrollment.
• Conditions that may impair intake or absorption such as inability to swallow capsules or tablets; known malabsorption syndrome; or baseline diarrhea ≤ Grade 1.
• Participation in other studies involving investigational drug(s) within 2 weeks prior to C1D1.

Where it is running

• University of Rochester Medical Center — Rochester, New York, United States
• GZA Ziekenhuizen campus Sint-Augustinus — Wilrijk, Antwerpen, Belgium
• Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy — Warsaw, Masovian Voivodeship, Poland
• Hospital Quirón Barceloma — Barcelona, Spain
• Hospital Universitari Vall d'Hebron — Barcelona, Spain

Full record on ClinicalTrials.gov

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