Exercise Training and Metabolic Flexibility in Prediabetes
Stopped early · Not applicable
Conditions studied: PreDiabetes, Sedentary Lifestyle
In brief
The purpose of the study is to determine if a 6-week exercise training program promotes exercise-induced metabolic flexibility, that is, the ability to switch fuel sources for energy, in older prediabetic adults.
Key facts
- Study ID
- NCT04051229
- Run by
- Wake Forest University Health Sciences
- People needed
- 10
- Starts
- 2019-10-29
- Expected to finish
- 2022-08-17
- Last updated by the study team
- 2023-11-07
Who can join
Age: 60 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- ≥60 years of age
- Sedentary prior to the start of the training program (self-reported: less than 30 minutes of exercise for no more than 1 day a week)
- Prediabetes (measured at first screening: HbA1c = 5.7-6.5%)
- Must be able to pick-up and consume study provided foods
- Willingness to provide informed consent and participate in the intervention
- Must obtain transportation to visits and intervention training sessions
- No contraindications for involvement in a moderate exercise training program or exercise testing procedures by self-report
You may not qualify if…
- Self-reported diagnosis of a metabolic or chronic disease such as cardiovascular disease, diabetes, Chronic Obstructive Pulmonary Disease, or movement disorders such as Parkinson's disease, Ataxia, Huntington's Disease
- Current or recent (<12 months) treatment for cancer
- Body Mass Index <18.5 or >/30.0 kg/m2
- Tobacco users
- Febrile or chronic infection within study period
- Aversion to testing procedures
- Hypertension, hyperthyroidism, hypothyroidism
- Unwilling to abstain from ingesting caffeine during study testing periods
- Unwilling to withhold medications that affect metabolic rate during testing periods
- Physically active (>30 minutes per day on more than 1 day per week)
- ECGs that indicate cardiac injury or contraindications to treadmill testing
- Allergic or intolerant to any study-provided foods
Where it is running
- Department of Health and Exercise Science Clinical Research Center — Winston-Salem, North Carolina, United States
- Wake Forest Baptist Medical Center Clinical Research Unit — Winston-Salem, North Carolina, United States
Full record on ClinicalTrials.gov
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