Respiratory Control and Narcotic Effects

Completed

Conditions studied: Ventilatory Depression, Opioid Intoxication, Opioid Toxicity

In brief

The aim of this study is to provide data that will assess the role of ventilatory chemosensitivity (respiratory drive) in determining postoperative respiratory depression due to opioids. In a group of patients requiring surgery and admission to hospital, before surgery, ventilatory chemosensitivity will be assessed in the presence or absence of an infusion of remifentanil. Parameters will be correlated with ventilatory depression events after surgery. A secondary aim is to determine whether respiratory depression is more likely during specific phases of sleep.

Key facts

Study ID

NCT04047550

Run by

Duke University

People needed

10

Starts

2018-03-08

Expected to finish

2019-02-09

Last updated by the study team

2020-08-27

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• 18 years of age or older, undergoing major abdominal or urological surgery requiring at least one overnight hospital stay

You may not qualify if…

• Pregnancy Adverse reaction to remifentanil Opioid-use within the past month Dependency on supplemental oxygen Brain injury in the past year Coronary artery disease Sickle cell disease.

Where it is running

• Duke University Medical Center — Durham, North Carolina, United States

Full record on ClinicalTrials.gov

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