Genetic Causes of Discrepant Clinic in Monogenic Twins

Recruiting now

Conditions studied: Rare Diseases, Genetic Predisposition to Disease

In brief

In the DISCO-TWIN study (prospective, open-label molecular-genetic study), twin pairs with one healthy and one affected twin with molecularly undiagnosed diseases will be analysed by means of omics technologies and/ or re-analysed using existing datasets. Phenotype and omics data will be shared within the University Hospital Tübingen and with external collaborators to improve the diagnostic rate of the subjects included in the study.

Key facts

Study ID

NCT04046796

Run by

University Hospital Tuebingen

People needed

50

Starts

2019-12-01

Expected to finish

2027-12-01

Last updated by the study team

2025-03-30

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Twin pair monozygotic clinically (phenotypic) discordant twins
• Unclear diagnosis
• Suspected (mono-)genetic cause of the disease in one twin

You may not qualify if…

• Missing informed consent of both twin/ legal representative
• No distinct phenotype

Where it is running

• University Hospital Tübingen — Tübingen, Germany (enrolling)

Full record on ClinicalTrials.gov

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