Fluoroethyltyrosine for Evaluation of Intracranial Neoplasms
Completed · Phase 2
Conditions studied: Intracranial Neoplasm, Low Grade Glioma, Recurrent Glioblastoma, Recurrent World Health Organization (WHO) Grade II Glioma, Recurrent WHO Grade III Glioma
In brief
This phase II trial studies how well F-18 fluoroethyltyrosine (fluoroethyltyrosine) works in detecting tumors in participants with intracranial tumors that have come back. FET accumulates in malignant cells within intracranial neoplasms and can be used to detect recurrent disease and characterize the grade of glial neoplasms. Imaging agents such as FET can help oncologist to see the tumor better during a positron emission tomography (PET) scan.
Key facts
- Study ID
- NCT04044937
- Run by
- Thomas Hope
- People needed
- 143
- Starts
- 2018-10-29
- Expected to finish
- 2024-03-31
- Last updated by the study team
- 2026-03-11
Who can join
Age: 3 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age > 3 years.
- Presence or suspicion of intracranial neoplasm in two populations.
- Population 1: Patients after primary treatment (radiation therapy and/or surgery) with suspicion of recurrence on magnetic resonance imaging (MRI). Three sub-populations will be considered:
- Recurrent metastatic lesions.
- Recurrent high-grade gliomas (grades 3 and 4).
- Recurrent low-grade gliomas (grades 1 and 2).
- Population 2: Patients prior to primary treatment with planned biopsy or surgical resection.
You may not qualify if…
- Patient with known incompatibility to PET or computed tomography (CT)/MRI scans.
- Patient unlikely to comply with study procedures, restrictions and requirements and judged by the investigator to be unsuitable for study participation.
- Sedation or anesthesia can be used for patients who cannot tolerate the exam.
Where it is running
- University of California, San Francisco — San Francisco, California, United States
Full record on ClinicalTrials.gov
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