ADP-A2M4CD8 as Monotherapy or in Combination With Either Nivolumab or Pembrolizumab in HLA-A2+ Subjects With MAGE-A4 Positive Tumors (SURPASS)
Running, not enrolling · Phase 1
Conditions studied: Endometrial Cancer, Esophageal Cancer, Esophagogastric Junction (EGJ), Gastric (Stomach) Cancer, Head and Neck Cancer, Melanoma, Ovarian Cancer, Non-small Cell Lung (NSCLC), Urothelial Cancer
In brief
This study will investigate the safety and tolerability of ADP-A2M4CD8 T-cell therapy in subjects who have the appropriate human leukocyte antigen (HLA) and MAGE-A4 tumor antigen. Tumor indications include endometrial, esophageal, esophagogastric junction (EGJ), gastric, head and neck, melanoma, non-small cell lung (NSCLC), ovarian or urothelial cancer.
Key facts
- Study ID
- NCT04044859
- Run by
- USWM CT, LLC
- People needed
- 120
- Starts
- 2019-08-20
- Expected to finish
- 2037-04-30
- Last updated by the study team
- 2026-04-07
Who can join
Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Name of Institution: Orlando Health Cancer Institute — Orlando, Florida, United States
- Massachusetts General Hospital — Boston, Massachusetts, United States
- Washington University - School of Medicine — St Louis, Missouri, United States
- Memorial Sloan Kettering Cancer Center — New York, New York, United States
- Duke University Medical Center, Duke Cancer Institute — Durham, North Carolina, United States
- OU Health Stephenson Cancer Center — Oklahoma City, Oklahoma, United States
- Sarah Cannon Research Institute — Nashville, Tennessee, United States
- M.D. Anderson Cancer Center — Houston, Texas, United States
- Froedtert Hospital and the Medical College of Wisconsin — Milwaukee, Wisconsin, United States
- Princess Margaret Cancer Centre — Toronto, Ontario, Canada
- Hospital Universitario 12 De Octubre — Madrid, Avenida de Cordoba S/n, Spain
- Clinica Universitaria de Navarra — Pío, Pamplona, Spain
- Hospital Clinico de Valencia — Ibanez, Valencia, Spain
- Hospital Universitario Vall d'Hebron — Barcelona, Spain
- Hospital Universitario Fundacion Jimenez Diaz — Madrid, Spain
- Hospital Universitario HM Sanchinarro CIOCC — Madrid, Spain
- Hospital Universitario Virgen del Rocio — Seville, Spain
Full record on ClinicalTrials.gov
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