Behavioral and Neural Representations of Subjective Effort Cost

Recruiting now · Not applicable

Conditions studied: Fatigue

In brief

The goal of this proposal is to understand the common and distinct behavioral and neural representations of subjective effort valuation, and how these representations are influenced by fatigue and changes in motivation. It is hypothesized that the brain will use overlapping and distinct neural circuits to represent cognitive and physical effort value, and that fatigue and enhanced motivation will influence the subjective value of effort.

Key facts

Study ID

NCT04041154

Run by

Hugo W. Moser Research Institute at Kennedy Krieger, Inc.

People needed

185

Starts

2018-08-01

Expected to finish

2029-12-31

Last updated by the study team

2026-01-26

Who can join

Age: 18 and older, up to 35. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Right-handed
• Age between 18 and 35 years old - Male or female
• Any ethnicity

You may not qualify if…

• Individuals with a history of any of the following will be excluded from the study:
• Neurological problems such as stroke, head injury, epilepsy, seizures, brain tumors, brain surgery, Parkinson's Disease (self- report)
• Diagnosed history of severe psychiatric disease such as depression, schizophrenia (self-report)
• Metal in the head or eyes
• If they are pregnant or suspect that you may be pregnant
• If they experience discomfort from the MRI scan, such as severe claustrophobia or excessive heating of tattoos

Where it is running

• Kennedy Krieger Institute — Baltimore, Maryland, United States (enrolling)

Full record on ClinicalTrials.gov

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