Use of Antibiotic Irrigation to Decrease Wound Infections in Pediatric Perforated Appendicitis

Running, not enrolling · Phase 2

Conditions studied: Perforated Appendicitis

In brief

The proposed study will investigate whether antibiotic irrigation using a gentamicin/clindamycin solution during laparoscopic appendectomy is superior in preventing postoperative wound infections and IAA in perforated appendicitis compared to suction without irrigation. This will be the first prospective study to compare these two options in pediatric PA.

Key facts

Study ID

NCT04039750

Run by

Prisma Health-Upstate

People needed

200

Starts

2019-07-25

Expected to finish

2026-12-01

Last updated by the study team

2026-01-27

Who can join

Age: any, up to 18. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Male or female, age 18 years or younger
• Scheduled to undergo laparoscopic appendectomy
• Preoperative or intra-operative diagnosis of perforated appendicitis (PA).
• Willingness to undergo treatments, provide written informed consent, and participate in follow-up.

You may not qualify if…

• Male or female older than 18 years of age
• Declined to undergo laparoscopic appendectomy
• Not willing to provide written informed consent or undergo randomization of treatment
• Pregnancy

Where it is running

• Prisma Health - Upstate — Greenville, South Carolina, United States

Full record on ClinicalTrials.gov

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