Ischemic Conditioning Improves Walking Function Post Stroke

Completed · Not applicable · Has a placebo group

Conditions studied: Stroke, Stroke, Ischemic, Stroke Hemorrhagic, Stroke, Cardiovascular

In brief

This innovative study will address scientific and clinical areas relatively unexplored in chronic stroke that could lead to greater recovery of walking. Ischemic Conditioning (IC) is a non-invasive, simple procedure that improves motor function, exercise performance and cardiovascular function in healthy controls, but it has never been applied to the stroke population. We postulate that IC enhances the recruitment of motoneurons and results in positive neural adaptations, improves vascular endothelial function and peripheral blood flow, and together these improvements result in an increased capacity to exercise and faster walking speed. Future studies will examine the effects of IC and traditional therapy at different time points of recovery post stroke, durability of IC, molecular mechanisms of neural and cardiovascular adaptation and the efficacy compared with other adjuncts.

Key facts

Study ID
NCT04038697
Run by
Medical College of Wisconsin
People needed
132
Starts
2018-12-20
Expected to finish
2026-01-09
Last updated by the study team
2026-05-04

Who can join

Age: 18 and older, up to 85. Sex: any. Healthy volunteers: accepted.

Where it is running

Full record on ClinicalTrials.gov

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