Vitamin C Supplementation Intervention

Completed · Not applicable · Has a placebo group

Conditions studied: Heart Failure

In brief

This study is to test a low-cost, simple vitamin C supplementation intervention, that is, comparing placebo to 500 mg/day vitamin C and 1 gram/day vitamin C daily to assess feasibility and acceptability of vitamin C supplementation and effects on serum vitamin C level, health-related quality of life (HRQOL), symptom burden, oxidative stress, and cardiac function.

Key facts

Study ID

NCT04036110

Run by

University of North Carolina, Chapel Hill

People needed

36

Starts

2018-08-14

Expected to finish

2020-06-16

Last updated by the study team

2021-03-09

Who can join

Age: 18 and older, up to 99. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patents recruited will have a diagnosis of chronic HF, either preserved or reduced ejection fraction. The diagnosis and etiology of chronic HF will be confirmed by a HF cardiologist using established criteria.
• Other criteria:
• have undergone evaluation of HF and optimization of medical therapy,
• vitamin C supplementation <500 mg/day
• have not been referred for heart transplantation,
• able to read and speak English,
• >1 month from any inpatient hospitalization

You may not qualify if…

• history of renal stones or renal disease (serum creatinine >1.5,
• history of glucose-6-phosphate dehydrogenase deficiency (G6PD) and cognitive impairment that precludes giving informed consent or ability to follow protocol instructions
• pregnant

Where it is running

• UNCH Meadowmont Clinic — Chapel Hill, North Carolina, United States

Full record on ClinicalTrials.gov

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