Role of Aerobic Exercise to Modulate Cardiotoxicity in Long Term Cancer Survivors Exposed to Anthracycline Therapy

Completed

Conditions studied: Cancer, Cardiotoxicity

In brief

Over 50% of the more than 270,000 childhood cancer survivors in the U.S. have been treated with anthracyclines and thus are at risk of developing cardiotoxicity. The impact of exercise training on LV structure has been extensively studied. Left ventricular hypertrophy and cardiac chamber enlargement with the accompanying ability to generate a large stroke volume are direct results of exercise training. Aerobic exercise therapy offers a non-pharmacological mechanism to modulate multiple gene expression pathways that may promote cardiac remodeling. No prior studies have investigated the efficacy of aerobic exercise in the prevention or treatment of anthracycline-induced cardiotoxicity. We hypothesize that exercise intervention leads to a reverse in adverse cardiac remodeling with improvement of global and regional myocardial function in patients exposed to anthracycline.

Key facts

Study ID

NCT04036032

Run by

Connecticut Children's Medical Center

People needed

47

Starts

2015-06-19

Expected to finish

2025-08-27

Last updated by the study team

2025-10-14

Who can join

Age: 9 and older, up to 99. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Long-term childhood cancer survivors greater than 9 years of age*
• Exposed to anthracycline chemotherapy * Age > 9 years of age was chosen to avoid the need for general anesthesia or sedation

You may not qualify if…

• Contraindications to CMRI*
• Individuals needing sedation to complete the cMRI
• Subject not able to perform stress test.
• Pregnancy**
• Non-English speaking individuals
• Orbital X-Ray confirmed to have metal in the eye or patient confirmed to have metal in the eye

Where it is running

• CT Children's Medical Center — Hartford, Connecticut, United States
• Nationwide Children's Hospital — Columbus, Ohio, United States

Full record on ClinicalTrials.gov

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