129Xe MRI in Pediatric Population With BPD

Withdrawn before enrolling · Phase 1

Conditions studied: Bronchopulmonary Dysplasia

In brief

Hyperpolarized (HP) gas magnetic resonance imaging (MRI) of the lungs offers additional information that cannot be obtained with CT scan, the current gold standard for imaging this disorder. As a nonionizing technique, MRI is an ideal modality for pulmonary imaging; in particular in the infant and pediatric population. Nevertheless, due to the low proton density of the lung parenchyma (only \~20% that of solid tissues), numerous air-tissue interfaces that lead to rapid signal decay, and cardiac and respiratory sources of motion that further degrade image quality , MRI has played a limited role in the evaluation of lung pathologies. In this setting, HP gas (using 129Xe) MRI may play a role in helping determine the regional distribution of alveolar sizes, partial pressure of oxygen, alveolar wall thickness, and gas transport efficiency of the microvasculature within the lungs of infants with a diagnosis of bronchopulmonary dysplasia (BPD).

Key facts

Study ID: NCT04035629
Run by: Xemed LLC
People needed: 0
Starts: 2026-08-01
Expected to finish: 2031-12-31
Last updated by the study team: 2026-02-05

Who can join

Age: any, up to 1. Sex: any. Healthy volunteers: accepted.

You may qualify if…

Infants admitted to the NICU at the Children's Hospital of Philadelphia with bronchopulmonary dysplasia who are followed by the Chronic Lung Disease Program.
Subjects mechanically ventilated either via and endotracheal tube or via a tracheostomy.
Subjects already receiving sedation as part of clinical care.

You may not qualify if…

Infants whom the primary care team deems to be unstable for transport to MRI

Where it is running

University of Pennsylvania — Philadelphia, Pennsylvania, United States

Full record on ClinicalTrials.gov

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