Febrile Disease Landscape in Cambodia Via Metagenomic Pathogen Sequencing
Recruiting now
Conditions studied: Vector-Borne Diseases, Emerging Pathogens
In brief
Background: Vector-borne diseases are caused by the bite of an infected mosquito, fly, flea, tick, or other blood-feeder. These diseases cause almost 1 million deaths per year. And they are on the rise, particularly in Southeast Asia in particular. Researchers think that these diseases make up about 10 percent of fevers in Cambodia. But many of these illnesses are never diagnosed. Studying these diseases can help find new ways to identify and treat them. Objective: To find pathogens in people who have a fever using metagenomic pathogen sequencing platforms. Eligibility: People aged at least 2 months years with a fever of at least 38 degrees Celsius or those diagnosed with infection by a pathogen of concern who visit the referral hospital in Cambodia. Close contacts of people diagnosed with infection by a pathogen of concern may also be enrolled. Design: Participants will be screened with their medical history. Children will be weighed to make sure they are big enough to give blood samples. Participants will share data about their sex, age, and where they live. They will answer more questions about their heath history. They will answer questions about and any places to which they have recently traveled. They will take a questionnaire. They will have a blood test. If they have respiratory symptoms, they will have a nasal swab. Participants may be contacted within 1-2 weeks (early) and/or within 3 months (late) from their enrollment date to provide an optional follow-up blood samples and nasal swabs.
Key facts
- Study ID
- NCT04034264
- Run by
- National Institute of Allergy and Infectious Diseases (NIAID)
- People needed
- 6500
- Starts
- 2019-07-23
- Expected to finish
- 2027-07-01
- Last updated by the study team
- 2026-07-30
Who can join
Age: 0 and older. Sex: any. Healthy volunteers: accepted.
You may not qualify if…
- Any underlying, chronic, or current medical condition that, in the opinion of the investigator, would interfere with participation in the study (e.g., inability or great difficulty in drawing blood).
- Any febrile individual who has had surgery in the prior month.
- Any patient who enrolled and exited this study within 30 days of the initial study blood draw, or afebrile close contact who enrolled and exited within 14 days.
Where it is running
- Kampong Speu Referral Hospital — Chbar Mon, Cambodia (enrolling)
- Kantha Bopha Hospital — Phnom Penh, Cambodia (enrolling)
- Khmer-Soviet Friendship Hospital — Phnom Penh, Cambodia (enrolling)
- National Pediatric Hospital — Phnom Penh, Cambodia (enrolling)
- Preah Kossomak Hospital — Phnom Penh, Cambodia (enrolling)
- Takeo District Referral Hospital — Takeo, Cambodia (enrolling)
Full record on ClinicalTrials.gov
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