Use of EBPT in Critically Ill Patients With AKI and/or Multiorgan Failure

Recruiting now

Conditions studied: Critical Illness, Acute Kidney Injury, Sepsis, Systemic Inflammatory Response Syndrome

In brief

The use of extracorporeal blood purification therapies (EBPT) is becoming increasingly widespread worldwide in everyday clinical practice, particularly in the critical care setting. Nonetheless, most of the clinical trials aimed at exploring the effect of EBPT on patients' long-term outcomes have failed to demonstrate consistent results regarding 28 day- or hospital- mortality rates. The aim of this observational prospective registry is to evaluate if there is a cluster of critically ill patients that mostly benefits from extracorporeal blood purification therapies with different EBPTs.

Key facts

Study ID

NCT04033224

Run by

Careggi Hospital

People needed

1000

Starts

2019-07-16

Expected to finish

2025-09-30

Last updated by the study team

2025-02-12

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• critically ill patients in the ICU
• one of this EPB therapy:
• CRRT/IHD/Hybrid therapies for support//replacement renal function
• immunomodulation achieved by "high cut-off membranes", "endotoxins and/or cytokines adsorbent membranes" or by high-volume hemofiltration

You may not qualify if…

• patients treated only by Cytosorb® and/or Toraymyxin® therapies

Where it is running

• Ospedale S. Giuseppe — Empoli, Firenze, Italy (enrolling)
• Ospedale Versilia — Lido di Camaiore, Lucca, Italy (enrolling)
• Humanitas Research Hospital — Rozzano, Milano, Italy (enrolling)
• IRCCS Policlinico S. Donato — San Donato Milanese, Milano, Italy (enrolling)
• Ospedale S. Gerardo — Monza, Monza-Brianza, Italy (enrolling)
• Ospedale A. Perrino — Brindisi, Italy (enrolling)
• Azienda Ospedaliero Universitaria Careggi — Florence, Italy (enrolling)
• Fondazione IRCCS Policlinico San Matteo — Pavia, Italy (enrolling)
• Ospedale S. Jacopo — Pistoia, Italy (enrolling)
• Ospedale S. Stefano — Prato, Italy (enrolling)
• Grande Ospedale Metropolitano "Bianchi Melacrino Morelli" — Reggio Calabria, Italy (enrolling)
• Policlinico Universitario Fondazione Agostino Gemelli — Roma, Italy (enrolling)
• Azienda Ospedaliero-Universitaria Sant'Andrea — Roma, Italy (enrolling)
• Ospedale Maria Vittoria — Torino, Italy (enrolling)
• Ospedale S. Bortolo — Vicenza, Italy (enrolling)

Full record on ClinicalTrials.gov

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