Cannabidiol, Morphine, Pain

Status unconfirmed · Phase 1

Conditions studied: CBD, Chronic Pain

In brief

The purpose of the proposed study is to investigate the interaction of cannabidiol (CBD) and morphine effects on pain sensitivity. Cannabidiol is a cannabinoid (similar to cannabis, or marijuana) present in marijuana that alters some of the effects of marijuana.

Key facts

Study ID

NCT04030442

Run by

Wayne State University

People needed

40

Starts

2019-05-01

Expected to finish

2025-01-26

Last updated by the study team

2024-02-29

Who can join

Age: 18 and older, up to 55. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Participants must report having smoked a cigarette (nicotine or marijuana) AND having taken an opioid on 3 or more occasions in their lifetime.
• Participants must be in good health to participate; those with certain contraindications will be excluded.
• All participants will undergo psychiatric evaluation and will be asked to report their substance use history by interview and structured questionnaire methods.
• Participants will undergo medical evaluations using medical history, physical exam, standard lab tests (complete blood chemistry, urinalysis, urine pregnancy test for females), and 12-lead ECG.

You may not qualify if…

• Serious psychiatric illness (e.g. psychotic or bipolar disorder, recent suicide attempts; severe depression)
• Substance Use Disorders other than Nicotine Use Disorder and Mild Cannabis Use Disorder
• Neurological diseases; cardiovascular problems (e.g. systolic BP >140 or <95 mmHg, diastolic BP >90 mmHg, abnormal ECG); pulmonary diseases; systemic diseases (e.g. liver, renal, inflammatory)
• Cognitive impairment (<80 IQ)
• Past-month medications that increase study risk
• Women who are pregnant (urine HCG), lactating (self-report), or if heterosexually active and not using (self-report) medically approved birth control (oral or depot contraception, IUD, condom/foam, sterilization, tubal ligation)
• Individuals unable to give informed consent will be excluded.

Where it is running

• Tolan Park Medical Building — Detroit, Michigan, United States (enrolling)

Full record on ClinicalTrials.gov

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