Skeletal Muscle Protein Synthesis: Traditional and Cluster Sets

Completed · Not applicable

Conditions studied: Resistance Exercise

In brief

Traditionally, when performing resistance exercise, repetitions are performed in a continuous manner resulting in a decrease in velocity, and thus power output. "Cluster" set is an alternative to counter the reduction in velocity and power output. Cluster sets incorporate a brief rest (15-30 seconds) between individual repetitions (inter-repetition rest) or group of repetitions (intra-set rest) within a set of resistive exercise. In contrast to traditional set configurations, which result in an almost linear decrease in force, velocity, and power -cluster sets maintain and/or attenuate the loss in power, primarily due to higher velocities. The purpose of this research is to compare the muscle protein synthesis response to acute bouts of cluster and traditional set configurations. Investigators will assess muscle protein synthesis rates before and after acute resistance exercise in 14 resistance-trained males and females (Age: 20-35; back squat 1.5 x body weight; 3 years of resistance training experience). The volunteers are required to be removed (at least six weeks) from all ergogenic levels of nutritional supplements that have previously been shown to affect protein synthesis. Blood and muscle biopsies will be collected as a part of testing. Further, subjects will be required to perform moderate-to-high intensity resistance exercise.

Key facts

Study ID

NCT04028726

Run by

University of Illinois at Urbana-Champaign

People needed

8

Starts

2018-08-25

Expected to finish

2019-07-15

Last updated by the study team

2019-07-24

Who can join

Age: 20 and older, up to 35. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Resistance-trained adults
• Back squat 1.5x body weight
• 3 years resistance-training experience
• Aged between 20-35 years

You may not qualify if…

• Tobacco use (previous 6 months)
• Alcohol consumption >10 drinks per week
• Metabolic disorders, diabetes, thyroid disease, hypogonadism
• Heart disease, arrhythmias, asthma
• History of uncontrolled hypertension
• Orthopaedic injury/surgery within the last year
• Hepatorenal, musculoskeletal, autoimmune, neuromuscular, or neurologic disease
• Consumed ergogenic levels of nutritional supplements that may affect muscle mass (i.e. creatine, HMB), insulin-like substances, or anabolic/catabolic pro-hormones (i.e. DHEA) within six weeks prior to the onset of the study
• Individuals consuming thyroid, androgenic, or other medications known to affect endocrine function
• Individuals on any medications known to affect protein metabolism (i.e. corticosteroids, non-steroidal anti- inflammatories, or prescription strength acne medications)
• Pregnant

Where it is running

• Freer Hall — Urbana, Illinois, United States

Full record on ClinicalTrials.gov

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