Biologic Mechanisms of Early Exercise After Intracerebral Hemorrhage

Completed · Not applicable

Conditions studied: Intracerebral Hemorrhage, Acute Ischemic Stroke

In brief

This study aims to determine whether in-bed cycle ergometry, early in the hospital course after a brain hemorrhage could balance damaging and reparative inflammation in the brain. Inflammatory factors of two groups of patients with brain hemorrhage will be compared, one group will receive in-bed cycling beginning 3 days after hemorrhage plus usual care and the other group will receive usual care only.

Key facts

Study ID: NCT04027049
Run by: Johns Hopkins University
People needed: 25
Starts: 2019-03-02
Expected to finish: 2021-02-24
Last updated by the study team: 2024-05-01

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Supratentorial intracerebral hemorrhage with or without intraventricular hemorrhage
Pre-morbid modified Rankin Score of 0-2
Patient must be able to provide informed consent or have a legally authorized representative to provide consent on patient's behalf

You may not qualify if…

Patients with known inflammatory conditions, infection requiring antibiotics or pregnancy
Patients receiving daily anti-inflammatory medications including but not limited to prednisone, methotrexate, non-steroidal anti-inflammatory medications (ibuprofen, naproxen, indomethacin, celecoxib) and aspirin >325mg
Glasgow Coma Score (GCS) 3 48 hours after admission
Patients in whom withdrawal of life support is being considered by surrogate decision makers
Injury to the lower extremities, hips or pelvis, weight >250 kg (weight limit of cycle), or body habitus precluding normal function of cycle

Where it is running

Johns Hopkins University, Department of Neurology — Baltimore, Maryland, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.