Phenotyping Genetic Risk for Type 2 Diabetes
Recruiting now · Not applicable
Conditions studied: Diabetes Mellitus, Type 2, Genetics
In brief
This study tests the hypothesis that non-diabetic individuals with a high genetic risk score for type 2 diabetes have impaired glucose tolerance and insulin resistance compared to those with a low genetic risk score for type 2 diabetes.
Key facts
- Study ID
- NCT04024631
- Run by
- University of Pennsylvania
- People needed
- 100
- Starts
- 2019-06-17
- Expected to finish
- 2026-06-30
- Last updated by the study team
- 2025-09-10
Who can join
Age: 10 and older, up to 70. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Age 10-70 years
- Prior participant of the UPenn Biobank or Center for Applied Genomics Biobank and agreed to be recontacted for future research.
- Adults with BMI 25kg/m2 or higher, children and adolescents with BMI 85th percentile or higher
You may not qualify if…
- prior diagnosis of type 1, type 2, or secondary diabetes
- use of medications that would impact glucose and insulin response such as steroids, metformin or other anti-diabetic medication
- acute illness that may impact insulin and glucose dynamics
- pregnancy
- hypothalamic obesity or related genetic disorder of metabolism
- recent systemic chemotherapy use
- gastrointestinal impairment or surgery that may impact absorption
- anemia
- major organ system illness or any underlying condition requiring regular medication or treatment that could make implementation of the protocol or interpretation of the study results difficult
- inability to comply with study protocol
Where it is running
- University of Pennsylvania — Philadelphia, Pennsylvania, United States (enrolling)
- Childrens Hospital of Philadelphia — Philadelphia, Pennsylvania, United States
Full record on ClinicalTrials.gov
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