Effects of Pine Cone Extract on Serum IgE Levels in Perennial Rhinitis
Status unconfirmed · Not applicable · Has a placebo group
Conditions studied: Perennial Allergic Rhinitis
In brief
The medicinal properties of pinecones have been used for years to treat a variety of illnesses. In the mouse model, an extract of pine cones, poly-phenylpropanoid-polysaccharide complex (PPC), has been shown to reduce total serum IgE levels as well as decreased production of IL-4, a cytokine associated with allergic disease. In this study, the investigators aim to determine the effects that PPC will have on total serum IgE levels in adult subjects with perennial rhinitis.
Key facts
- Study ID
- NCT04024033
- Run by
- University of South Florida
- People needed
- 36
- Starts
- 2011-03-01
- Expected to finish
- 2023-10-01
- Last updated by the study team
- 2023-05-10
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Subjects with perennial allergic rhinitis with or without seasonal allergic rhinitis
- Male or female participants must be 18 years of age or older
You may not qualify if…
- Subjects receiving subcutaneous allergen immunotherapy or monoclonal anti-IgE (omalizumab)
- Subject with hypersensitivity to PPC
- Pregnant subjects (lactating post-partum women will be allowed to participate)
- Subjects who are unable to cooperate/comply with study procedures or communicate with investigator in order to successfully complete the study
- Subjects with severe skin disorders such as atopic dermatitis, dermatographism, psoriasis who could not have allergy skin testing and who have no prior skin testing completed within 3 years
- Subjects with an infirmity, disability, or geographical location which seems likely to prevent regular attendance for patient visits
Where it is running
- Usf Asthma Allergy and Immunology Cru — Tampa, Florida, United States
Full record on ClinicalTrials.gov
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