Do Knee Injections Offer Benefit With Knee Arthritis Pain

Completed

Conditions studied: Knee Osteoarthritis

In brief

Corticosteroid and viscosupplementation injections have been used for years to treat osteoarthritic pain in knees. Recent studies have varied in reporting the effectiveness with these injections. None have been found to analyze pain scores between the groups though. This study aims to evaluate the effectiveness of corticosteroid injection (a single injection of 1 cc of 40 mg kenalog: 4 cc 0.5% Naropin) and viscosupplementation injection (Euflexxa and Synvisc, both are 2 cc of the medication given in 3 injections over a 3 week period). This will be analyzed with a modified visual analog scale over a period of time. An initial VAS will be collected prior to the first injection in the clinic. With the viscosupplementation injections, a VAS will be collected prior to injections 2 and 3 as well. These VAS are logged in the patient's chart. For both types of injections, the participant will be called and a VAS will be recorded 6 weeks post injection and 3 month post injection. These VAS will NOT be logged in the participant's chart. All VAS will be collected/recorded by the principal investigator. Statistical analysis will be conducted with a paired t-test (p\<0.05 with a confidence interval at 95%) from the pre-injection VAS and VAS subsequently.

Key facts

Study ID

NCT04017949

Run by

University of Pittsburgh

People needed

75

Starts

2019-08-21

Expected to finish

2020-03-01

Last updated by the study team

2020-04-06

Who can join

Age: 40 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• The participant has been previously been diagnosed with knee osteoarthritis by one of the investigator's surgeons in the office.
• The injection was recommended by another clinician
• Age of the pool of participants will be 40 years old and over
• All gender and BMI will be considered
• Severity of osteoarthritis will not be a determinant

You may not qualify if…

• Patients who are receiving any injections based upon medical recommendation by the primary investigator will be excluded from the study.
• Patients previously diagnosed with rheumatoid arthritis will be excluded from the study

Where it is running

• Three Rivers Orthopedic Associates — Pittsburgh, Pennsylvania, United States

Full record on ClinicalTrials.gov

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