Relationship About Pregnancy Health and Offspring Developmental &Behavioral Outcomes

Recruiting now

Conditions studied: Children Behavior Problem, Pregnancy

In brief

This topic puts forward a hypothesis: genetic and environmental factors such as major depressive disorder during pregnancy, nutritional status of vitamin A, D, E, and folic acid, intestinal microecology, and bisphenol A exposure, may affect the cognitive development level of the offspring through the genetic correlation with attention deficit hyperactivity disorder, developmental delay/intellectual disability, and major depressive disorder, allelic heterogeneity and pleiotropy of ITIH3 mediated by SNP and CACNB2, neurotransmitters like dopamine, and metabolic pathways, thereby increasing the risk of attention deficit hyperactivity disorder and developmental delay/intellectual disability prevalence on offspring. This topic planning from allelic heterogeneity and pleiotropy of attention deficit hyperactivity disorder and major depressive disorder mediated by SNP, neurotransmitters like dopamine, and metabolic pathways, explores deeply the influences on children's development level and the risk of common neurological disorder caused by genetic and environmental factors during pregnancy, looking for reasonable prevention, early diagnosis of biomarkers and therapeutic targets, in order to provide data support for further improvement and revision of national mother and infant healthcare policy .

Key facts

Study ID

NCT04017286

Run by

Chen Li

People needed

3000

Starts

2019-07-01

Expected to finish

2028-12-31

Last updated by the study team

2021-02-01

Who can join

Age: 0 and older, up to 6. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Inclusion criteria for pregnant women: Aged 20\~49;
• no cognitive impairment, able to complete the scale test;
• Hamilton Depression Scale (HAMD questionnaire) is normal (HAMD score <8 points) or mild to moderate positive (HAMD questionnaire score: 8\~35 points);
• Participants are asked for their own written informed content for the study;

You may not qualify if…

• Patients receiving anti-depression therapy during the first 6 months of gestation or during pregnancy;
• Patients with severe depression with scores of no less than 35 points in the HAMD questionnaire;
• Patients with other mental disorders;
• Patients with neurological diseases;
• Patients with cognitive dysfunction.

Where it is running

• Wanzhou Health Center for Women and Children — Chongqing, Chongqing Municipality, China (enrolling)
• The People's Hospital of Yubei District of Chongqing City — Chongqing, Chongqing Municipality, China
• Chongqing First People's Hospital of Liangjiang New Area — Chongqing, Chongqing Municipality, China
• The Central Hospital of Jiangjin District of Chongqing City — Chongqing, Chongqing Municipality, China
• The Maternal and Child Health Hospital of Hainan Province — Haikou, Hainan, China

Full record on ClinicalTrials.gov

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