Imaging to Improve Brain Stimulation

Completed

Conditions studied: Depressive Disorder

In brief

This study investigates how brains change as a result of a treatment for depression called repetitive transcranial magnetic stimulation (rTMS). People who receive rTMS will have pictures of their brains and brain activity taken by a magnetic resonance imaging (MRI) scanner before and after their treatment, as well as up to three times during the six-week treatment course. These images will be examined to see if the rTMS is placed correctly to help treat their symptoms, and what changes in brain activity are happening during the rTMS treatment

Key facts

Study ID

NCT04016402

Run by

VA Office of Research and Development

People needed

42

Starts

2019-10-24

Expected to finish

2025-12-31

Last updated by the study team

2026-08-03

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Veteran beginning TMS therapy for the treatment of MDD at the Providence VAMC Neuromodulation Clinic
• Age between 18 and 80 years
• Able to read, verbalize, understand, and voluntarily sign the informed consent form
• Structured Clinical Interview for DSM-5 (SCID-5) confirmed diagnosis of MDD

You may not qualify if…

• Contraindications to MRI (e.g. implanted metal or electronic devices)
• Montreal Cognitive Assessment (MoCA) score < 26
• Pregnant

Where it is running

• VA Palo Alto Health Care System, Palo Alto, CA — Palo Alto, California, United States
• Providence VA Medical Center, Providence, RI — Providence, Rhode Island, United States

Full record on ClinicalTrials.gov

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