Markers of Atherosclerosis in Overweight, Postmenopausal Women Following Daily Watermelon Consumption

Completed · Not applicable

Conditions studied: Postmenopausal, Overweight and Obesity

In brief

The primary purpose of this study is to determine the effectiveness of six weeks of watermelon puree supplementation, compared to control (no treatment), on blood antioxidant capacity, inflammation markers in the blood, biomarkers of metabolism in the blood, and cardiovascular disease markers in the blood, and biomarkers in the blood related to watermelon ingestion in overweight post-menopausal women. The secondary purpose is to compare body composition and body mass between the watermelon supplement group and the control group.

Key facts

Study ID

NCT04015544

Run by

Appalachian State University

People needed

52

Starts

2014-04-01

Expected to finish

2014-07-01

Last updated by the study team

2019-07-11

Who can join

Age: 50 and older, up to 75. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• Female
• 50 to 75 years of age,
• have not menstruated for at least 1 year (menopause),
• have a BMI of ≥25 kg/m2,
• nonsmoker with
• no diagnosed history of chronic diseases including: coronary heart disease, stroke, cancer, type 1 or 2 diabetes mellitus, or rheumatoid arthritis;
• may not regularly consume large quantities of L-citrulline/L-arginine rich foods (red meat, tuna fish, cheese, nuts),
• may not regularly take L-citrulline/L-arginine supplements,
• may not use anti-hypertension medications (including diuretic medications),
• may not use exogenous ovarian hormones, or
• may not use medications known to influence inflammation within the two weeks of the study period (specifically non-steroidal anti-inflammatory drugs; NSAIDS).

You may not qualify if…

• Male,
• younger than 50 or older than 75 years of age,
• menstruated within the last year,
• have a BMI of <25 kg/m2, smoker,
• diagnosed history of chronic diseases including: coronary heart disease, stroke, cancer, type 1 or 2 diabetes mellitus, or rheumatoid arthritis;
• regularly consume large quantities of L-citrulline/L-arginine rich foods (red meat, tuna fish, cheese, nuts),
• regularly take L-citrulline/L-arginine supplements,
• use anti-hypertension medications (including diuretic medications),
• use exogenous ovarian hormones, or
• use medications known to influence inflammation within the two weeks of the study period (specifically non-steroidal anti-inflammatory drugs; NSAIDS).

Where it is running

• Appalachian State University — Boone, North Carolina, United States

Full record on ClinicalTrials.gov

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