Evaluation of Central Sensitization, Fear-Avoidance, and Pain-Pressure Threshold With Chronic Pain After Hysterectomy

Recruiting now

Conditions studied: Hysterectomy, Chronic Pain, Central Sensitisation, Anxiety Depression

In brief

Phase 1 (started in July 2019): Central Sensitization Inventory (CSI), Fear-Avoidance Components Scale (FACS), pain-pressure threshold are factors associated with chronic post-hysterectomy pain (CPHP), but a complete understanding on the development of CPHP is lacking. The study aims to identify clinically-relevant factors for CPHP that can be reliably assessed preoperatively. === Phase 2 (anticipated start May 2022): In addition to above factors, the association between heart rate variability (HRV) parameters, anxiety level, anticipated pain, and anticipated analgesia requirement with significant postoperative pain and CPHP will be investigated.

Key facts

Study ID

NCT04014829

Run by

KK Women's and Children's Hospital

People needed

436

Starts

2019-07-23

Expected to finish

2027-12-01

Last updated by the study team

2024-11-26

Who can join

Age: 21 and older, up to 80. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• Age 21 to 80 years old
• American Society of Anesthesiologists Physical Scale (ASA) I to III
• Benign gynaecological indications for hysterectomy
• Elective abdominal or laparoscopic hysterectomy

You may not qualify if…

• Vaginal hysterectomy
• Uterine prolapse, endometriosis, malignant disease, or pelvic pain as main indication for surgery
• History of drug dependence or recreational drug use
• History of chronic pain syndrome
• Current chronic daily treatment with corticosteroids, excluding inhaled steroids
• Allergy to study drugs
• Major heart surgery
• Heart transplant
• Pacemaker inserted
• Baseline non-sinus cardiac rhythm

Where it is running

• KK Women's and Children's Hospital — Singapore, Singapore (enrolling)

Full record on ClinicalTrials.gov

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