O2 Transport and Utilization in Health and Lung Disease

Withdrawn before enrolling · Phase 1 · Has a placebo group

Conditions studied: COPD, Tetrahydrobiopterin Deficiency, Oxidative Stress

In brief

Skeletal muscle dysfunction is a frequent and clinically relevant systemic manifestation of Chronic Pulmonary Obstructive Disease (COPD), which is still poorly understood. Therefore, the focus of this study is on the role of a deficit in tetrahydrobiopterin and nitric oxide synthase uncoupling induced by chronic oxidative stress on metabolic and vascular abnormalities in skeletal muscle of patients suffering from COPD.

Key facts

Study ID

NCT04014712

Run by

University of Massachusetts, Amherst

People needed

0

Starts

2021-04-01

Expected to finish

2022-08-01

Last updated by the study team

2023-12-19

Who can join

Age: 18 and older, up to 85. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• All subjects must be between the age of 18 and 85 years;
• For the COPD cohort, patients with a diagnosis of stable COPD (i.e., those not experiencing an acute exacerbation of symptoms) and spirometric evidence of airway obstruction (FEV1 <80% predicted, FEV/FVC<0.70);
• Ability to perform motor tests;
• Ability to provide informed consent

You may not qualify if…

• uncontrolled hypertension;
• hyperlipidemia;
• recent exacerbation;
• Major cardiovascular event procedure (<3 months);
• Pregnancy
• known significant hepatic, renal disease, active substance abuse
• contraindication to MRI, claustrophobia

Where it is running

• Institute of Applied Life Sciences — Amherst, Massachusetts, United States

Full record on ClinicalTrials.gov

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