Precision-T: A Study of Orca-T in Recipients Undergoing Allogeneic Transplantation for Hematologic Malignancies
Running, not enrolling · Phase 1
Conditions studied: Acute Myeloid Leukemia, Acute Lymphoid Leukemia, Myelodysplastic Syndromes, Acute Leukemia, Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN), Chronic Myeloid Leukemia
In brief
This study will evaluate the safety, tolerability, and efficacy of Orca-T, an allogeneic stem cell and T-cell immunotherapy biologic manufactured for each patient (transplant recipient) from the mobilized peripheral blood of a specific, unique donor. It is composed of purified hematopoietic stem and progenitor cells (HSPCs), purified regulatory T cells (Tregs), and conventional T cells (Tcons) in participants undergoing myeloablative allogeneic hematopoietic cell transplant transplantation for hematologic malignancies.
Key facts
- Study ID
- NCT04013685
- Run by
- Orca Biosystems, Inc.
- People needed
- 155
- Starts
- 2019-11-21
- Expected to finish
- 2027-04-01
- Last updated by the study team
- 2026-06-02
Who can join
Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.
Where it is running
- City of Hope — Duarte, California, United States
- Ronald Reagan UCLA Medical Center — Los Angeles, California, United States
- UC Davis — Sacramento, California, United States
- Stanford Health Care — Stanford, California, United States
- Colorado Blood Cancer Institute — Denver, Colorado, United States
- University of Miami Hospital and Clinics - Sylvester Comprehensive Cancer Center — Miami, Florida, United States
- Moffitt Cancer Center — Tampa, Florida, United States
- Winship Cancer Institute - Emory University — Atlanta, Georgia, United States
- University of Chicago — Chicago, Illinois, United States
- The University of Kansas Hospital — Kansas City, Kansas, United States
- Massachusetts — Boston, Massachusetts, United States
- University of Michigan Health System - Michigan Medicine — Ann Arbor, Michigan, United States
- Weill Cornell Medicine - New York-Presbyterian Hospital — New York, New York, United States
- Memorial Sloan Kettering Cancer Center — New York, New York, United States
- Cleveland Clinic — Cleveland, Ohio, United States
- OU Health Stephenson Cancer Center — Oklahoma City, Oklahoma, United States
- Oregon Health & Sciences University - Knight Cancer Institute — Portland, Oregon, United States
- Sarah Cannon Research Institute — Nashville, Tennessee, United States
- Vanderbilt University — Nashville, Tennessee, United States
- University of Texas MD Anderson Cancer Center — Houston, Texas, United States
- University of Utah - Huntsman Cancer Institute — Salt Lake City, Utah, United States
Full record on ClinicalTrials.gov
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