Cascade Testing in Families With Newly Diagnosed Hereditary Breast and Ovarian Cancer Syndrome
Running, not enrolling
Conditions studied: BRCA-Mutated Ovarian Carcinoma, BRIP1 Gene Mutation, MSH2 A636P, MLH1 Gene Mutation, MSH6 Gene Mutation, PMS2 Gene Mutation, EPCAM, RAD51C Gene Mutation
In brief
Identification of BRCA mutations in ovarian cancer patients may help guide cancer therapies, prognosis, post-operative screening, and other preventative treatments beyond the initial diagnosis. Likewise, genetic testing of ovarian cancer patients for these germline mutations provides invaluable information for families regarding cancer risk, genetic testing, and subsequently indication for risk-reducing surgery. Cascade testing provides a unique opportunity to identify carriers of a deleterious BRCA mutation which can allow for surgical and chemoprevention of prevention of ovarian cancer. There is currently no literature on the rates of referral for the family members.
Key facts
- Study ID
- NCT04009148
- Run by
- NYU Langone Health
- People needed
- 118
- Starts
- 2019-03-01
- Expected to finish
- 2027-04-23
- Last updated by the study team
- 2026-05-14
Who can join
Age: 18 and older, up to 99. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- All subjects must have a diagnosis of epithelial ovarian cancer, Fallopian tube caner or primary peritoneal cancer with a known pathogenic genetic mutation.
- All subjects must agree to participate.
- All subjects must have first or second degree relatives who have not been diagnosed with the same genetic mutation.
- A previous diagnosis of cancer in the subject's first or second degree relative is allowed.
You may not qualify if…
- Subjects whose first and/or second degree relatives have already been tested with the subject's known mutations, and no other viable family members are available for testing.
Where it is running
- NYU Langone Health — New York, New York, United States
Full record on ClinicalTrials.gov
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