Long-Term PF-06651600 for the Treatment of Alopecia Areata

Completed · Phase 3

Conditions studied: Alopecia Areata

In brief

This is a global Phase 3 study to evaluate the safety and effectiveness of an investigational study drug (called PF-06651600) in adults and adolescents (12 years and older) who have alopecia areata. Eligible patients from the prior studies B7931005 (NCT02974868) and B7981015 (NCT03732807) will have an opportunity to enroll as well as patients who have not previously participated in either of these studies. The study is open-label and all patients entering the study will receive active study drug. A sub-study of approximately 60 adult patients who are participating in the B7981032 study will be conducted at select sites in the US, Australia and Canada. The sub-study will evaluate the immune response to tetanus and meningococcal vaccines in patients who have received a minimum of 6 months of 50 mg PF-06651600.

Key facts

Study ID

NCT04006457

Run by

Pfizer

People needed

1057

Starts

2019-07-18

Expected to finish

2026-02-26

Last updated by the study team

2026-04-09

Who can join

Age: 12 and older. Sex: any. Healthy volunteers: not accepted.

Where it is running

• The University of Alabama at Birmingham — Birmingham, Alabama, United States
• The University of Alabama at Birmingham, Department of Dermatology — Birmingham, Alabama, United States
• Mosaic Dermatology — Beverly Hills, California, United States
• Univ of California, Irvine, Dermatology Clinical Research Center — Irvine, California, United States
• Dermatology Specialists Inc. — Murrieta, California, United States
• University of California, San Francisco — San Francisco, California, United States
• Kaiser Permanente Clinical Trials Unit — San Francisco, California, United States
• Southern California Dermatology, Inc. — Santa Ana, California, United States
• University of Colorado Anschutz Medical Campus — Aurora, Colorado, United States
• University of Colorado Hospital Clinical and Translational Research Center — Aurora, Colorado, United States
• University of Colorado Hospital Outpatient Pavilion — Aurora, Colorado, United States
• Yale School of Medicine, Yale Center for Clinical Investigations — New Haven, Connecticut, United States
• Medstar Georgetown University Hospital - Department of Otolaryngology — Washington D.C., District of Columbia, United States
• Medstar Georgetown University Hospital-Dept of Otolaryngology — Washington D.C., District of Columbia, United States
• MedStar Washington Hospital Center — Washington D.C., District of Columbia, United States
• Medstar Georgetown University Hospital - Department of Pediatrics — Washington D.C., District of Columbia, United States
• Siperstein Dermatology Group — Boynton Beach, Florida, United States
• Park Avenue Dermatology — Orange Park, Florida, United States
• ForCare Clinical Research — Tampa, Florida, United States
• Velocity Clinical Research - Boise — Meridian, Idaho, United States
• Northwestern Medical Group — Chicago, Illinois, United States
• Northwestern Medicine Diagnostic Testing Center — Chicago, Illinois, United States
• Northwestern Medicine — Chicago, Illinois, United States
• Northwestern Memorial Hospital Investigational Drug Service Pharmacy — Chicago, Illinois, United States
• The University of Alabama at Birmingham Hosptial Outreach Lab — Birmingham, Alabama, United States

Full record on ClinicalTrials.gov

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